“This patient had a high risk for relapsing from acute myeloid leukaemia, making his remission even more remarkable,” Aribi said. The patient did not experience serious medical issues after transplant. The remission is necessary because a transplant is an intensive procedure that can cause serious complications. Most patients achieve remission after one therapy. Under the care of City of Hope hematologist Dr Ahmed Aribi, the patient received three different therapies to get him into remission before receiving a transplant. It demonstrates that research and clinical care developed and led at City of Hope are changing the meaning of an HIV diagnosis for patients across the United States and the world,” said Dr John Zaia, director of City of Hope’s Center for Gene Therapy. “The City of Hope patient is another major advancement. They are working to start a clinical trial using CAR T therapy, which has the potential to provide HIV patients with a lifelong viral suppression without ART. City of Hope CAR T scientist working in a lab. Leveraging their expertise in cellular immunotherapy, City of Hope scientists have also developed chimeric antigen receptor (CAR) T cells that can target and kill HIV-infected cells and control HIV in preclinical research. The remission is necessary because a transplant is an intensive procedure that can cause serious complications.Ĭity of Hope is a leader in treating patients with blood cancers, and has pioneered the use of gene-modified blood stem cell transplants to test whether stem cells can be engineered to be resistant to HIV infection. City of Hope made that possible, and I am beyond grateful.” “I never thought I would live to see the day that I no longer have HIV. “When I was diagnosed with HIV in 1988, like many others, I thought it was a death sentence,” the man, who wishes not to be identified, said. “The City of Hope patient’s case, if the right donor can be identified, may open up the opportunity for more older patients living with HIV and blood cancers to receive a stem cell transplant and go into remission for both diseases,” Dickter added. But now, he can celebrate this medical milestone.” “He saw many of his friends die from AIDS in the early days of the disease and faced so much stigma when he was diagnosed with HIV in 1988. “We were thrilled to let him know that his HIV is in remission and he no longer needs to take antiretroviral therapy that he had been on for over 30 years,” said Dr Jana Dickter, City of Hope associate clinical professor in the Division of Infectious Diseases, who presented the data at an AIDS 2022 press conference on Wednesday. The City of Hope patient was the oldest patient to undergo a transplant with HIV and leukaemia and go into remission from both conditions. Like the others, she had been living with HIV for a number of years and needed treatment for leukaemia. Cord blood is used to supply blood stem cells for transplants for patients unable to find matched adult donors. Like Timothy Ray Brown, the “Berlin patient” and Adam Castillejo, the “London patient”, the City of Hope patient developed a blood cancer and received stem cells from a donor who had a rare gene mutation (CCR5 Delta 32 on the CD4 cells) making them nearly immune to HIV.Įarlier this year, a woman in the US was also reported to have been in remissio n from HIV for over a year following a stem cell transplant using cells from an umbilical cord of a donor, an unrelated newborn child, with the same genetic mutation. The City of Hope patient received the transplant nearly three and a half years ago, and is older than the three previous patients with HIV who have gone into remission after receiving stem cell treatment for a blood cancer. The 66-year-old man, who was diagnosed with HIV in 1988, has been in remission 17 months after stopping antiretroviral therapy (ART) following a stem cell transplant for leukaemia. MONTREAL – A fourth person has been “cured” of HIV after receiving a stem cell transplant for leukaemia at the City of Hope Hospital in the US.
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